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Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the Nucleosome Remodelling and Deacetylation (NuRD) complex that regulates gene expression. CHD4 is essential for growth of multiple patient derived melanoma xenografts and for breast cancer. Here we show that CHD4 regulates...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Coassolo, Sébastien, Davidson, Guillaume, Negroni, Luc, Gambi, Giovanni, Daujat, Sylvain, Romier, Christophe, Davidson, Irwin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979715/
https://ncbi.nlm.nih.gov/pubmed/33741961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21960-4
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