First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G

BACKGROUND: CAR-T cells immunotherapy is a breakthrough in the treatment of hematological malignancies such as acute lymphoblastic leukemia (ALL) and B-cell malignancies. However, CAR-T therapies face major hurdles such as the lack of tumor-specific antigen (TSA), and immunosuppressive tumor microen...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Anna, François, Bole-Richard, Elodie, LeMaoult, Joel, Escande, Marie, Lecomte, Martin, Certoux, Jean-Marie, Souque, Philippe, Garnache, Francine, Adotevi, Olivier, Langlade-Demoyen, Pierre, Loustau, Maria, Caumartin, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978334/
https://ncbi.nlm.nih.gov/pubmed/33737343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001998
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