GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity

Rationale: Albuminuria is an early clinical feature in the progression of diabetic nephropathy (DN). Podocyte insulin resistance is a main cause of podocyte injury, playing crucial roles by contributing to albuminuria in early DN. G protein-coupled receptor 43 (GPR43) is a metabolite sensor modulati...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Lu, Jian, Chen, Pei Pei, Zhang, Jia Xiu, Li, Xue Qi, Wang, Gui Hua, Yuan, Ben Yin, Huang, Si Jia, Liu, Xiao Qi, Jiang, Ting Ting, Wang, Meng Ying, Liu, Wen Tao, Ruan, Xiong Zhong, Liu, Bi Cheng, Ma, Kun Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978296/
https://ncbi.nlm.nih.gov/pubmed/33754024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.56598
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