Assisting PNA transport through cystic fibrosis human airway epithelia with biodegradable hybrid lipid-polymer nanoparticles

Cystic fibrosis (CF) is characterized by an airway obstruction caused by a thick mucus due to a malfunctioning Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. The sticky mucus restricts drugs in reaching target cells limiting the efficiency of treatments. The development of new a...

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Published in:Sci Rep
Main Authors: Comegna, Marika, Conte, Gemma, Falanga, Andrea Patrizia, Marzano, Maria, Cernera, Gustavo, Di Lullo, Antonella Miriam, Amato, Felice, Borbone, Nicola, D’Errico, Stefano, Ungaro, Francesca, d’Angelo, Ivana, Oliviero, Giorgia, Castaldo, Giuseppe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973768/
https://ncbi.nlm.nih.gov/pubmed/33737583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85549-z
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