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Metabolic engineering of probiotic Escherichia coli for cytolytic therapy of tumors
Bacterial cancer therapy was developed using probiotic Escherichia coli Nissle 1917 (EcN) for medical intervention of colorectal cancer. EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter (P(BAD)). The intrinsic limitation of P(BAD) for the gene expression i...
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| 出版年: | Sci Rep |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7971005/ https://ncbi.nlm.nih.gov/pubmed/33712706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85372-6 |
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