Viral interleukin-6 encoded by an oncogenic virus promotes angiogenesis and cellular transformation by enhancing STAT3-mediated epigenetic silencing of caveolin 1

Kaposi’s sarcoma (KS) caused by oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) is a highly angiogenic and invasive vascular tumor and the most common AIDS-associated cancer. KSHV-encoded viral interleukin-6 (vIL-6) is implicated in the development of KSHV-induced malignancies; however, the...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Li, Wan, Wang, Qingxia, Qi, Xiaoyu, Guo, Yuanyuan, Lu, Hongmei, Chen, Yuheng, Lu, Zhongmou, Yan, Qin, Zhu, Xiaofei, Jung, Jae U., Tosato, Giovanna, Gao, Shou-Jiang, Lu, Chun
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970339/
https://ncbi.nlm.nih.gov/pubmed/32393833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1317-1
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