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Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice

OBJECTIVE: To determine the contribution of the gut microbiota to the development of injury-induced osteoarthritis (OA). DESIGN: OA was induced using the destabilized medial meniscus (DMM) model in 20 germ-free (GF) C57BL/6J male mice housed in a gnotobiotic facility and 23 strain-matched specific p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Osteoarthritis Cartilage
Prif Awduron: Ulici, V., Kelley, K.L., Azcarate-Peril, M.A., Cleveland, R.J., Sartor, R.B., Schwartz, T.A., Loeser, R.F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970023/
https://ncbi.nlm.nih.gov/pubmed/29857156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2018.05.016
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