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SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca(2+)

Coronaviruses are a major infectious disease threat, and include the zoonotic-origin human pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry of coronaviruses into host cells is mediated by the spike (S) protein. In our previous ESR studies, the local membrane ordering ef...

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Foilsithe in:J Mol Biol
Main Authors: Lai, Alex L., Freed, Jack H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier Ltd. 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969826/
https://ncbi.nlm.nih.gov/pubmed/33744314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166946
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