Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept

Background: Chronic low-grade inflammation and alterations in innate and adaptive immunity were reported in Type 2 diabetes (T2D). Here, we investigated the abundance and activation of T cells in the bone marrow (BM) of patients with T2D. We then verified the human data in a murine model and tested...

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Vydáno v:Front Immunol
Hlavní autoři: Santopaolo, Marianna, Sullivan, Niall, Thomas, Anita Coral, Alvino, Valeria Vincenza, Nicholson, Lindsay B., Gu, Yue, Spinetti, Gaia, Kallikourdis, Marinos, Blom, Ashley, Madeddu, Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969721/
https://ncbi.nlm.nih.gov/pubmed/33746953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.609406
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