Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors

Pexidartinib is a kinase inhibitor that induces tumor response and improvements in symptoms and functional outcomes in adult patients with symptomatic tenosynovial giant cell tumor (TGCT). A population pharmacokinetic (PK) model for pexidartinib and its metabolite, ZAAD, was developed, and effects o...

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Veröffentlicht in:J Clin Pharmacol
Hauptverfasser: Yin, Ophelia, Wagner, Andrew J., Kang, Jia, Knebel, William, Zahir, Hamim, van de Sande, Michiel, Tap, William D., Gelderblom, Hans, Healey, John H., Shuster, Dale, Stacchiotti, Silvia
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Pharmacometrics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969430/
https://ncbi.nlm.nih.gov/pubmed/33043474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1753
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