Exercise Intolerance in Cystic Fibrosis: Importance of Skeletal Muscle

PURPOSE: Exercise intolerance, evaluated by O(2) consumption, predicts mortality in Cystic Fibrosis (CF). People with CF exhibit skeletal muscle dysfunctions that may contribute to an imbalance between O(2) delivery and utilization. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, increases...

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Pubblicato in:Med Sci Sports Exerc
Autori principali: Rodriguez-Miguelez, Paula, Seigler, Nichole, Ishii, Haruki, Crandall, Reva, McKie, Kathleen T., Forseen, Caralee, Harris, Ryan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969358/
https://ncbi.nlm.nih.gov/pubmed/33105385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1249/MSS.0000000000002521
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