SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m(6)A-modified mRNAs

N (6)-Methyladenosine (m(6)A) is the most abundant modification within diverse RNAs including mRNAs and lncRNAs and is regulated by a reversible process with important biological functions. Human YTH domain family 2 (YTHDF2) selectively recognized m(6)A-RNAs to regulate degradation. However, the pos...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Hou, Guofang, Zhao, Xian, Li, Lian, Yang, Qianqian, Liu, Xiaojia, Huang, Caihu, Lu, Runhui, Chen, Ran, Wang, Yanli, Jiang, Bin, Yu, Jianxiu
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2021
Sujets:
RNA and RNA-protein complexes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969013/
https://ncbi.nlm.nih.gov/pubmed/33577677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab065
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