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A confinable home-and-rescue gene drive for population modification

Homing-based gene drives, engineered using CRISPR/Cas9, have been proposed to spread desirable genes throughout populations. However, invasion of such drives can be hindered by the accumulation of resistant alleles. To limit this obstacle, we engineer a confinable population modification home-and-re...

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Publicat a:eLife
Autors principals: Kandul, Nikolay P, Liu, Junru, Bennett, Jared B, Marshall, John M, Akbari, Omar S
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968924/
https://ncbi.nlm.nih.gov/pubmed/33666174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65939
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