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Age-related impairment of autophagy in cervical motor neurons

Neuromuscular dysfunction is common in old age. Damaged cytoplasmic structures aggregate with aging, especially in post-mitotic cells like motor neurons. Autophagy is a ubiquitous cell process that aids in the clearance of damaged aggregates. Accordingly, we hypothesized that autophagy is impaired i...

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Publicado en:Exp Gerontol
Autores principales: Pareja-Cajiao, Miguel, Gransee, Heather M., Stowe, Jessica M., Rana, Sabhya, Sieck, Gary C., Mantilla, Carlos B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968728/
https://ncbi.nlm.nih.gov/pubmed/33290859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2020.111193
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