Enhanced ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by employing polyhydroxybutyrate as an intracellular carbon reservoir and optimizing carbon addition

BACKGROUND: Ascomycin is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. As a secondary metabolite, the production of ascomycin is often limited by the shortage of precursors during the late fermentation phase. Polyhydroxybutyrate is an intracellular polymer a...

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Publicat a:Microb Cell Fact
Autors principals: Wang, Pan, Yin, Ying, Wang, Xin, Wen, Jianping
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968196/
https://ncbi.nlm.nih.gov/pubmed/33731113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01561-y
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