A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia

BACKGROUND: New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with a novel proposed mechanism of action. The first phase 3 clinical trial of GV-971 has been completed in China. METHODS: We conducted a phase 3, double-blin...

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Publicat a:Alzheimers Res Ther
Autors principals: Xiao, Shifu, Chan, Piu, Wang, Tao, Hong, Zhen, Wang, Shuzhen, Kuang, Weihong, He, Jincai, Pan, Xiaoping, Zhou, Yuying, Ji, Yong, Wang, Luning, Cheng, Yan, Peng, Ying, Ye, Qinyong, Wang, Xiaoping, Wu, Yuncheng, Qu, Qiumin, Chen, Shengdi, Li, Shuhua, Chen, Wei, Xu, Jun, Peng, Dantao, Zhao, Zhongxin, Li, Yansheng, Zhang, Junjian, Du, Yifeng, Chen, Weixian, Fan, Dongsheng, Yan, Yong, Liu, Xiaowei, Zhang, Wei, Luo, Benyan, Wu, Wenyuan, Shen, Lu, Liu, Chunfeng, Mao, Peixian, Wang, Qiumei, Zhao, Qianhua, Guo, Qihao, Zhou, Yongtao, Li, Yi, Jiang, Lijun, Ren, Wenwei, Ouyang, Yingjun, Wang, Yan, Liu, Shuai, Jia, Jianjun, Zhang, Nan, Liu, Zhonglin, He, Raoli, Feng, Tingyi, Lu, Wenhui, Tang, Huidong, Gao, Ping, Zhang, Yingchun, Chen, Lanlan, Wang, Lei, Yin, You, Xu, Qun, Xiao, Jinsong, Cong, Lin, Cheng, Xi, Zhang, Hui, Gao, Dan, Xia, Minghua, Lian, Tenghong, Peng, Guoping, Zhang, Xu, Jiao, Bin, Hu, Hua, Chen, Xueyan, Guan, Yihui, Cui, Ruixue, Huang, Qiu, Xin, Xianliang, Chen, Hongjian, Ding, Yu, Zhang, Jing, Feng, Teng, Cantillon, Marc, Chen, Kewei, Cummings, Jeffrey L., Ding, Jian, Geng, Meiyu, Zhang, Zhenxin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967962/
https://ncbi.nlm.nih.gov/pubmed/33731209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-021-00795-7
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