Baseline Hedgehog Pathway Activation and Increase of Plasma Wnt1 Protein Are Associated with Resistance to Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer

SIMPLE SUMMARY: Wnt and Hedgehog (Hh) pathways are associated with stemness profile and with resistance to anti-tumor therapies. Pre-clinical data have suggested a role of these pathways in resistance to immune checkpoint inhibitors (ICIs). Here we evaluated the expression and levels of Shh and Wnt...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Mehlman, Camille, Takam Kamga, Paul, Costantini, Adrien, Julié, Catherine, Dumenil, Coraline, Dumoulin, Jennifer, Ouaknine, Julia, Giraud, Violaine, Chinet, Thierry, Emile, Jean-François, Giroux Leprieur, Etienne
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962040/
https://ncbi.nlm.nih.gov/pubmed/33807552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13051107
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