NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac hypertrophy and inflammation. The myokine irisin can inhibit NLRP3 activation, although its exact mechanism of action is un...

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Publicado no:Cell Death Discov
Main Authors: Yue, Rongchuan, Zheng, Zaiyong, Luo, Yu, Wang, Xiaobo, Lv, Mingming, Qin, Dan, Tan, Qingqing, Zhang, Yulong, Wang, Tao, Hu, Houxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961005/
https://ncbi.nlm.nih.gov/pubmed/33723236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00434-y
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