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Overcoming the challenges associated with CD3+ T-cell redirection in cancer

The development of bispecific antibodies that redirect the cytotoxic activity of CD3+ T cells to tumours is a promising immunotherapeutic strategy for the treatment of haematological malignancies and solid cancers. Since the landmark FDA approval at the end of 2014 of the anti-CD3 × anti-CD19 bispec...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Singh, Ajit, Dees, Sundee, Grewal, Iqbal S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960983/
https://ncbi.nlm.nih.gov/pubmed/33469153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-01225-5
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