Comparative Assessment of the Activity of Racemic and Dextrorotatory Forms of Thioctic (Alpha-Lipoic) Acid in Low Back Pain: Preclinical Results and Clinical Evidences From an Open Randomized Trial

Peripheral neuropathies, characterized by altered nociceptive and muscular functions, are related to oxidative stress. Thioctic acid is a natural antioxidant existing as two optical isomers, but most clinically used as racemic mixture. The present study investigated the central nervous system’s chan...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Pacini, Alessandra, Tomassoni, Daniele, Trallori, Elena, Micheli, Laura, Amenta, Francesco, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo, Traini, Enea
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959756/
https://ncbi.nlm.nih.gov/pubmed/33732153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.607572
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