GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice

The lysosomal storage disease Niemann–Pick type C (NPC) is caused by impaired cholesterol efflux from lysosomes, which is accompanied by secondary lysosomal accumulation of sphingomyelin and glucosylceramide (GlcCer). Similar to Gaucher disease (GD), patients deficient in glucocerebrosidase (GCase)...

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Bibliographic Details
Published in:	Int J Mol Sci
Main Authors:	van der Lienden, Martijn J. C., Aten, Jan, Marques, André R. A., Waas, Ingeborg S. E., Larsen, Per W. B., Claessen, Nike, van der Wel, Nicole N., Ottenhoff, Roelof, van Eijk, Marco, Aerts, Johannes M. F. G.
Format:	Artigo
Language:	Inglês
Published:	MDPI 2021
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7959463/ https://ncbi.nlm.nih.gov/pubmed/33802460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052532
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GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice

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