Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy

BACKGROUND: High-mobility group box 1 (HMGB1) is a multifunctional redox-sensitive protein involved in various intracellular (eg, chromatin remodeling, transcription, autophagy) and extracellular (inflammation, autoimmunity) processes. Regarding its role in cancer development/progression, paradoxica...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Hubert, Pascale, Roncarati, Patrick, Demoulin, Stephanie, Pilard, Charlotte, Ancion, Marie, Reynders, Celia, Lerho, Thomas, Bruyere, Diane, Lebeau, Alizee, Radermecker, Coraline, Meunier, Margot, Nokin, Marie-Julie, Hendrick, Elodie, Peulen, Olivier, Delvenne, Philippe, Herfs, Michael
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2021
Fag:
Basic Tumor Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959241/
https://ncbi.nlm.nih.gov/pubmed/33712445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001966
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