A versatile platform for locus-scale genome rewriting and verification

Routine rewriting of loci associated with human traits and diseases would facilitate their functional analysis. However, existing DNA integration approaches are limited in terms of scalability and portability across genomic loci and cellular contexts. We describe Big-IN, a versatile platform for tar...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Brosh, Ran, Laurent, Jon M., Ordoñez, Raquel, Huang, Emily, Hogan, Megan S., Hitchcock, Angela M., Mitchell, Leslie A., Pinglay, Sudarshan, Cadley, John A., Luther, Raven D., Truong, David M., Boeke, Jef D., Maurano, Matthew T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958457/
https://ncbi.nlm.nih.gov/pubmed/33649239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023952118
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