Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain

Previous studies have demonstrated that the synaptic EphB1 receptor tyrosine kinase is a major mediator of neuropathic pain, suggesting that targeting the activity of this receptor might be a viable therapeutic option. Therefore, we set out to determine if any FDA-approved drugs can act as inhibitor...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ahmed, Mahmoud S., Wang, Ping, Nguyen, Ngoc Uyen Nhi, Nakada, Yuji, Menendez-Montes, Ivan, Ismail, Muhammad, Bachoo, Robert, Henkemeyer, Mark, Sadek, Hesham A., Kandil, Enas S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958374/
https://ncbi.nlm.nih.gov/pubmed/33627480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016265118
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