Homozygous IL37 mutation associated with infantile inflammatory bowel disease

Interleukin (IL)-37, an antiinflammatory IL-1 family cytokine, is a key suppressor of innate immunity. IL-37 signaling requires the heterodimeric IL-18R1 and IL-1R8 receptor, which is abundantly expressed in the gastrointestinal tract. Here we report a 4-mo-old male from a consanguineous family with...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Zinan Z., Zhang, Yu, He, Tingyan, Sweeney, Colin L., Baris, Safa, Karakoc-Aydiner, Elif, Yao, Yikun, Ertem, Deniz, Matthews, Helen F., Gonzaga-Jauregui, Claudia, Malech, Harry L., Su, Helen C., Ozen, Ahmet, Smith, Kenneth G. C., Lenardo, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958356/
https://ncbi.nlm.nih.gov/pubmed/33674380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009217118
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