Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis

Ki-67 is a nuclear protein that is expressed in all proliferating vertebrate cells. Here, we demonstrate that, although Ki-67 is not required for cell proliferation, its genetic ablation inhibits each step of tumor initiation, growth, and metastasis. Mice lacking Ki-67 are resistant to chemical or g...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Mrouj, Karim, Andrés-Sánchez, Nuria, Dubra, Geronimo, Singh, Priyanka, Sobecki, Michal, Chahar, Dhanvantri, Al Ghoul, Emile, Aznar, Ana Bella, Prieto, Susana, Pirot, Nelly, Bernex, Florence, Bordignon, Benoit, Hassen-Khodja, Cedric, Villalba, Martin, Krasinska, Liliana, Fisher, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958263/
https://ncbi.nlm.nih.gov/pubmed/33658388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026507118
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