Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis

SIMPLE SUMMARY: Obese breast cancer patients have an increased risk for metastasis; however, the mechanisms are not well characterized. Here, we show that obesity promotes rapid mammary tumor growth and enhances metastases in mice. Within the lungs of non-tumor-bearing mice, obesity increased recrui...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Hillers-Ziemer, Lauren E., Williams, Abbey E., Janquart, Amanda, Grogan, Caitlin, Thompson, Victoria, Sanchez, Adriana, Arendt, Lisa M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957630/
https://ncbi.nlm.nih.gov/pubmed/33670906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13051005
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