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The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations
The translocator protein (TSPO) is a 18kDa transmembrane protein, ubiquitously present in human mitochondria. It is overexpressed in tumor cells and at the sites of neuroinflammation, thus representing an important biomarker, as well as a promising drug target. In mammalian TSPO, there are cholester...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7956637/ https://ncbi.nlm.nih.gov/pubmed/33652554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26051250 |
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