ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.: Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for clinical application. H...

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Udgivet i:Nat Biotechnol
Main Authors: Cui, Liyang, Gouw, Arvin M., LaGory, Edward L., Guo, Shenghao, Attarwala, Nabeel, Tang, Yao, Qi, Ji, Chen, Yun-Sheng, Gao, Zhou, Casey, Kerriann M., Bazhin, Arkadiy A., Chen, Min, Hu, Leeann, Xie, Jinghang, Fang, Mingxi, Zhang, Cissy, Zhu, Qihua, Wang, Zhiyuan, Giaccia, Amato J., Gambhir, Sanjiv Sam, Zhu, Weiping, Felsher, Dean W., Pegram, Mark D., Goun, Elena A., Le, Anne, Rao, Jianghong
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956242/
https://ncbi.nlm.nih.gov/pubmed/33077961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0707-9
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