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RNA guide complementarity prevents self-targeting in type VI CRISPR systems

All immune systems use precise target recognition to interrogate foreign invaders. During CRISPR-Cas immunity, prokaryotes capture short spacer sequences from infecting viruses and insert them into the CRISPR array. Transcription and processing of the CRISPR locus generates small RNAs containing the...

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Publicado en:Mol Cell
Main Authors: Meeske, Alexander J., Marraffini, Luciano A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955661/
https://ncbi.nlm.nih.gov/pubmed/30122537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.013
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