Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes

BACKGROUND: NKX6.1 is a transcription factor for insulin, as well as a marker for β cell maturity. Abnormal NKX6.1 expression in β cells, such as translocation from the nucleus to cytoplasm or lost expression, has been shown as a marker for β cell dedifferentiation. METHODS: We obtained pancreatic s...

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Pubblicato in:BMC Endocr Disord
Autori principali: Liu, Tengli, Sun, Peng, Zou, Jiaqi, Wang, Le, Wang, Guanqiao, Liu, Na, Liu, Yaojuan, Ding, Xuejie, Zhang, Boya, Liang, Rui, Wang, Shusen, Shen, Zhongyang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955633/
https://ncbi.nlm.nih.gov/pubmed/33711989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12902-021-00708-7
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