Multiple polymerase acidic (PA) I38X substitutions in influenza A(H1N1)pdm09 virus permit polymerase activity and cause reduced baloxavir inhibition

BACKGROUND: Baloxavir marboxil is an antiviral drug that targets the endonuclease activity of the influenza virus polymerase acidic (PA) protein. PA I38T/M/F substitutions reduce its antiviral efficacy. OBJECTIVES: To understand the effects of the 19 possible amino acid (AA) substitutions at PA 38 o...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Antimicrob Chemother
Päätekijät: Jones, Jeremy C, Pascua, Philippe N Q, Harrington, Walter N, Webby, Richard J, Govorkova, Elena A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953318/
https://ncbi.nlm.nih.gov/pubmed/33351916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa527
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