Synthesis, inhibitory activity and oral dosing formulation of AV5124, the structural analogue of influenza virus endonuclease inhibitor baloxavir

BACKGROUND: The development and clinical implementation of the cap-dependent endonuclease (CEN) inhibitor baloxavir marboxil was a breakthrough in influenza therapy, but it was associated with the emergence of drug-resistant variants. OBJECTIVES: To design and synthesize structural analogues of CEN...

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Bibliografiske detaljer
Udgivet i:J Antimicrob Chemother
Main Authors: Ivashchenko, Andrei A, Mitkin, Oleg D, Jones, Jeremy C, Nikitin, Alexander V, Koryakova, Angela G, Karapetian, Ruben N, Kravchenko, Dmitry V, Mochalov, Stephan V, Ryakhovskiy, Alexey A, Aladinskiy, Vladimir, Leneva, Irina A, Falynskova, Irina N, Glubokova, Ekaterina A, Govorkova, Elena A, Ivachtchenko, Alexandre V
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953317/
https://ncbi.nlm.nih.gov/pubmed/33367751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa524
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