Solution structure of multi-domain protein ER-60 studied by aggregation-free SAXS and coarse-grained-MD simulation

Multi-domain proteins (MDPs) show a variety of domain conformations under physiological conditions, regulating their functions through such conformational changes. One of the typical MDPs, ER-60 which is a protein folding enzyme, has a U-shape with four domains and is thought to have different domai...

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Udgivet i:Sci Rep
Main Authors: Okuda, Aya, Shimizu, Masahiro, Morishima, Ken, Inoue, Rintaro, Sato, Nobuhiro, Urade, Reiko, Sugiyama, Masaaki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952739/
https://ncbi.nlm.nih.gov/pubmed/33707747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85219-0
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