Breast tumor kinase (Brk/PTK6) mediates advanced cancer phenotypes via SH2-domain dependent activation of RhoA and aryl hydrocarbon receptor (AhR) signaling

Protein tyrosine kinase 6 (PTK6; also called Brk) is overexpressed in 86% of breast cancer patients; high PTK6 expression predicts poor outcome. We reported PTK6 induction by HIF/GR complexes in response to either cellular or host stress. However, PTK6-driven signaling events in the context of TNBC...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Dwyer, Amy R., Kerkvliet, Carlos Perez, Krutilina, Raisa I., Playa, Hilaire C., Parke, Deanna N., Thomas, Warner A., Smeester, Branden A., Moriarity, Branden S., Seagroves, Tiffany N., Lange, Carol A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951948/
https://ncbi.nlm.nih.gov/pubmed/33172975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0295
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