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Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease
OBJECTIVES: Isradipine is a dihydropyridine calcium channel inhibitor that has demonstrated concentration‐dependent neuroprotective effects in animal models of Parkinson’s disease (PD) but failed to show efficacy in a phase 3 clinical trial. The objectives of this study were to model the plasma phar...
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| Udgivet i: | Ann Clin Transl Neurol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7951102/ https://ncbi.nlm.nih.gov/pubmed/33460320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.51300 |
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