Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of Porphyromonas gingivalis

Our previous studies showed that a combination of a DNA plasmid encoding Flt3 ligand (pFL) and CpG oligodeoxynucleotides 1826 (CpG ODN) (FL/CpG) as a nasal adjuvant provoked antigen-specific immune responses. In this study, we investigated the efficacy of a nasal vaccine consisting of FimA as the st...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Kataoka, Kosuke, Kawabata, Shigetada, Koyanagi, Kayo, Hashimoto, Yoshiya, Miyake, Tatsuro, Fujihashi, Kohtaro
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948520/
https://ncbi.nlm.nih.gov/pubmed/33717178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.634923
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