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Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB–DnaK bichaperone system
The ClpB–DnaK bichaperone system reactivates aggregated cellular proteins and is essential for survival of bacteria, fungi, protozoa, and plants under stress. AAA+ ATPase ClpB is a promising target for the development of antimicrobials because a loss of its activity is detrimental for survival of ma...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7948422/ https://ncbi.nlm.nih.gov/pubmed/33187983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015413 |
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