Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1

Suppressive mechanisms operating within T cells are linked to immune dysfunction in the tumor microenvironment. We have previously reported using adoptive T cell immunotherapy models that tumor–bearing mice treated with a regimen of proteasome inhibitor, bortezomib - a dipeptidyl boronate, show incr...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Renrick, Ariana N., Thounaojam, Menaka C., de Aquino, Maria Teresa P., Chaudhuri, Evan, Pandhare, Jui, Dash, Chandravanu, Shanker, Anil
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946819/
https://ncbi.nlm.nih.gov/pubmed/33717088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.607044
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