Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative

Hck, a Src family nonreceptor tyrosine kinase (SFK), has recently been established as an attractive pharmacological target to improve pulmonary function in COVID-19 patients. Hck inhibitors are also well known for their regulatory role in various malignancies and autoimmune diseases. Curcumin has be...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Chakraborty, Manas Pratim, Bhattacharyya, Sudipta, Roy, Souryadip, Bhattacharya, Indira, Das, Rahul, Mukherjee, Arindam
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946438/
https://ncbi.nlm.nih.gov/pubmed/33617879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100449
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