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Epigenetic modulation reveals differentiation state specificity of oncogene addiction
Hyperactivation of the MAPK signaling pathway motivates the clinical use of MAPK inhibitors for BRAF-mutant melanomas. Heterogeneity in differentiation state due to epigenetic plasticity, however, results in cell-to-cell variability in the state of MAPK dependency, diminishing the efficacy of MAPK i...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7943789/ https://ncbi.nlm.nih.gov/pubmed/33750776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21784-2 |
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