Transcriptomic Profiling of In Vitro Tumor-Stromal Cell Paracrine Crosstalk Identifies Involvement of the Integrin Signaling Pathway in the Pathogenesis of Mesenteric Fibrosis in Human Small Intestinal Neuroendocrine Neoplasms

AIM: Analysis of the pathophysiology of mesenteric fibrosis (MF) in small intestinal neuroendocrine tumors (SI-NETs) in an in vitro paracrine model and in human SI-NET tissue samples. METHODS: An indirect co-culture model of SI-NET cells KRJ-I and P-STS with stromal cells HEK293 was designed to eval...

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Vydáno v:Front Oncol
Hlavní autoři: Laskaratos, Faidon-Marios, Levi, Ana, Schwach, Gert, Pfragner, Roswitha, Hall, Andrew, Xia, Dong, von Stempel, Conrad, Bretherton, Josephine, Thanapirom, Kessarin, Alexander, Sarah, Ogunbiyi, Olagunju, Watkins, Jennifer, Luong, Tu Vinh, Toumpanakis, Christos, Mandair, Dalvinder, Caplin, Martyn, Rombouts, Krista
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943728/
https://ncbi.nlm.nih.gov/pubmed/33718208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.629665
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