Transient Delivery of a KCNQ2/3-Specific Channel Activator 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus

Exposure to loud noise can cause hearing loss and tinnitus in mice and humans. In mice, one major underlying mechanism of noise-induced tinnitus is hyperactivity of auditory brainstem neurons, due at least in part, to decreased Kv7.2/3 (KCNQ2/3) potassium channel activity. In our previous studies, w...

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Vydáno v:J Assoc Res Otolaryngol
Hlavní autoři: Marinos, Laura, Kouvaros, Stylianos, Bizup, Brandon, Hambach, Bryce, Wipf, Peter, Tzounopoulos, Thanos
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943662/
https://ncbi.nlm.nih.gov/pubmed/33575914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10162-021-00786-3
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