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Disrupting upstream translation in mRNAs is associated with human disease
Ribosome-profiling has uncovered pervasive translation in non-canonical open reading frames, however the biological significance of this phenomenon remains unclear. Using genetic variation from 71,702 human genomes, we assess patterns of selection in translated upstream open reading frames (uORFs) i...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7943595/ https://ncbi.nlm.nih.gov/pubmed/33750777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21812-1 |
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