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Disrupting upstream translation in mRNAs is associated with human disease

Ribosome-profiling has uncovered pervasive translation in non-canonical open reading frames, however the biological significance of this phenomenon remains unclear. Using genetic variation from 71,702 human genomes, we assess patterns of selection in translated upstream open reading frames (uORFs) i...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Lee, David S. M., Park, Joseph, Kromer, Andrew, Baras, Aris, Rader, Daniel J., Ritchie, Marylyn D., Ghanem, Louis R., Barash, Yoseph
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943595/
https://ncbi.nlm.nih.gov/pubmed/33750777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21812-1
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