Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R which can inhibit the two entry pathways (endocytic pathway and TMPRSS2-mediated surface pathway) of SARS-CoV-2 in cells. The endosomal acidi...

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Publicado no:Nat Commun
Principais autores: Zhao, Hanjun, To, Kelvin K. W., Lam, Hoiyan, Zhou, Xinxin, Chan, Jasper Fuk-Woo, Peng, Zheng, Lee, Andrew C. Y., Cai, Jianpiao, Chan, Wan-Mui, Ip, Jonathan Daniel, Chan, Chris Chung-Sing, Yeung, Man Lung, Zhang, Anna Jinxia, Chu, Allen Wing Ho, Jiang, Shibo, Yuen, Kwok-Yung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943568/
https://ncbi.nlm.nih.gov/pubmed/33750821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21825-w
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