Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation

Liquid-liquid phase separation (LLPS) can drive formation of diverse and essential macromolecular structures, including those specified by viruses. Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) genomes associate with the viral encoded Latency-Associated Nuclear Antigen (LANA) to form stable nuclear...

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發表在:PLoS Pathog
Main Authors: Vladimirova, Olga, De Leo, Alessandra, Deng, Zhong, Wiedmer, Andreas, Hayden, James, Lieberman, Paul M.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2021
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943007/
https://ncbi.nlm.nih.gov/pubmed/33471863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009231
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