Delayed rise of oral fluid antibodies, elevated BMI, and absence of early fever correlate with longer time to SARS-CoV-2 RNA clearance in an longitudinally sampled cohort of COVID-19 outpatients

BACKGROUND: Sustained molecular detection of SARS-CoV-2 RNA in the upper respiratory tract (URT) in mild to moderate COVID-19 is common. We sought to identify host and immune determinants of prolonged SARS-CoV-2 RNA detection. METHODS: Ninety-five outpatients self-collected mid-turbinate nasal, orop...

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Published in:medRxiv
Main Authors: Antar, Annukka A. R., Yu, Tong, Pisanic, Nora, Azamfirei, Razvan, Tornheim, Jeffrey A., Brown, Diane M., Kruczynski, Kate, Hardick, Justin P., Sewell, Thelio, Jang, Minyoung, Church, Taylor, Walch, Samantha N., Reuland, Carolyn, Bachu, Vismaya S., Littlefield, Kirsten, Park, Han-Sol, Ursin, Rebecca L., Ganesan, Abhinaya, Kusemiju, Oyinkansola, Barnaba, Brittany, Charles, Curtisha, Prizzi, Michelle, Johnstone, Jaylynn R., Payton, Christine, Dai, Weiwei, Fuchs, Joelle, Massaccesi, Guido, Armstrong, Derek T., Townsend, Jennifer L., Keller, Sara C., Demko, Zoe O, Hu, Chen, Wang, Mei-Cheng, Sauer, Lauren M., Mostafa, Heba H., Keruly, Jeanne C., Mehta, Shruti H., Klein, Sabra L., Cox, Andrea L., Pekosz, Andrew, Heaney, Christopher D., Thomas, David L., Blair, Paul W., Manabe, Yukari C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941665/
https://ncbi.nlm.nih.gov/pubmed/33688688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.02.21252420
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