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Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine
Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level. It showed that prefrontal ATP level decreased after morphine injection and the event amplitude tended to decrease wit...
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| Publicado no: | iScience |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7940985/ https://ncbi.nlm.nih.gov/pubmed/33733073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102213 |
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