Functional differences and similarities in activated peripheral blood mononuclear cells by lipopolysaccharide or phytohemagglutinin stimulation between human and cynomolgus monkeys

BACKGROUND: The monkey is a primary species used in toxicological research. However, the failures of preclinical studies to predict a life-threatening “cytokine storm”, which, for instance, rapidly occurred in six healthy volunteers with the CD28 superagonist monoclonal antibody (mAb) TGN1412 in the...

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Bibliographische Detailangaben
Veröffentlicht in:Ann Transl Med
Hauptverfasser: Lin, Zhi, Huang, Ying, Jiang, Hua, Zhang, Di, Yang, Yanwei, Geng, Xingchao, Li, Bo
Format: Artigo
Sprache:Inglês
Veröffentlicht: AME Publishing Company 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7940909/
https://ncbi.nlm.nih.gov/pubmed/33708884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm-20-4548
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