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Prioritizing non-coding regions based on human genomic constraint and sequence context with deep learning
Elucidating functionality in non-coding regions is a key challenge in human genomics. It has been shown that intolerance to variation of coding and proximal non-coding sequence is a strong predictor of human disease relevance. Here, we integrate intolerance to variation, functional genomic annotatio...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7940646/ https://ncbi.nlm.nih.gov/pubmed/33686085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21790-4 |
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